Inhibition of hypothalamic leukemia inhibitory factor exacerbates diet-induced obesity phenotype
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چکیده
منابع مشابه
Unsaturated Fatty Acids Revert Diet-Induced Hypothalamic Inflammation in Obesity
BACKGROUND In experimental models, hypothalamic inflammation is an early and determining factor in the installation and progression of obesity. Pharmacological and gene-based approaches have proven efficient in restraining inflammation and correcting the obese phenotypes. However, the role of nutrients in the modulation of hypothalamic inflammation is unknown. METHODOLOGY/PRINCIPAL FINDINGS H...
متن کاملInhibition of gold thioglucose-induced hypothalamic obesity by glucose analogues.
LIKUSKI, HENRY J., ALBERT F. DEBONS, AND ROGER J. CLOUTIER. Inhibition of go Id thioghcose-induced hypothalamic obesity by glucose analogues. Am. J. Physiol. 2 12(3) 669-676. 1967.--Female CBA mice were used to determine the effect of the glucose inhibitors, 2-deoxy-n-glucose and 2-amino-2-deoxy-oglucose on gold thioglucose-induced hypothalamic obesity. A marked inhibition in the incidence of o...
متن کاملInhibition of gold thioglucose-induced hypothalamic obesity by glucose analogued
LIKUSKI, HENRY J., ALBERT F. DEBONS, AND ROGER J. CLOUTIER. Inhibition of go Id thioghcose-induced hypothalamic obesity by glucose analogues. Am. J. Physiol. 2 12(3) 669-676. 1967.--Female CBA mice were used to determine the effect of the glucose inhibitors, 2-deoxy-n-glucose and 2-amino-2-deoxy-oglucose on gold thioglucose-induced hypothalamic obesity. A marked inhibition in the incidence of o...
متن کاملP104: Obesity-Induced Neuroinflammation: Focus on Hypothalamic Inflammation
Obesity is a Health issue around the world. Obesity is not limited to body weight, generally associated with low grade inflammation and with a cluster of disorders generally referred to as "metabolic syndrome". Regarding obesity and relapse, long-term concentration was set on the hypothalamus. Most recently,obesity- Originated neuroinflammation has been shown to affect other brain str...
متن کاملMacrophage Migration Inhibitory Factor Inhibition Is Deleterious for High-Fat Diet-Induced Cardiac Dysfunction
AIMS Development of metabolic syndrome is associated with impaired cardiac performance, mitochondrial dysfunction and pro-inflammatory cytokine increase, such as the macrophage migration inhibitory factor MIF. Depending on conditions, MIF may exert both beneficial and deleterious effects on the myocardium. Therefore, we tested whether pharmacological inhibition of MIF prevented or worsened meta...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2017
ISSN: 1742-2094
DOI: 10.1186/s12974-017-0956-9